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Mechanistically, high-glucose conditions induced robust upregulation of BMP4 and increased phosphorylation of its downstream effectors Smad1/5/9, driving tumorigenic signaling

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As obesity treatment becomes increasingly personalized, clinicians are often choosing among several highly effective therapies rather than deciding whether to treat at all, said co-author Yuan Lu, Assistant Professor of Cardiology at Penn Considering blood pressure, cholesterol, and glucose control together could be key to aligning with each patients overall, individualized cardiometabolic profile. Three focal points for the future Chen identified a collection of priorities for the next phase of GLP-1 research and obesity care

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